Clonal selection articles from across Nature Portfolio. Atom; RSS Feed; Definition. Clonal selection is a process proposed to explain how a single B or T cell that recognizes an antigen that ...

Then, in 2021, the lab showed that clonal burst happen by what they dubbed “inertial” cell cycling, in which B cells multiply continuously without selection between each round. Neither finding ...

An atlas of B-cell clonal distribution in the human body. Nature Biotechnology, 2017; DOI: 10.1038/nbt.3942; Cite This Page: MLA; APA; Chicago; University of Pennsylvania School of Medicine.

Predominance of CD4+ T Cells in T-Cell/Histiocyte-Rich Large B-Cell Lymphoma and Identification of a Subset of Patients With Peripheral B-Cell Lymphopenia, American Journal of Clinical Pathology ...

More specifically, B cells in the dark zone of the germinal center, where most of the cell division occurs, exhibited lower AID activity, leading to fewer mutations per cycle.

“B-cell clones are highly diverse. We have over 100 billion different B-cell types at any time. So even at 1 million B-cells sequenced, we definitely did not sample all of them,” Hershberg said. “That ...

The advantageous mutations that drive clonal hematopoiesis are under positive selection, just like mutations in cancer genes which are responsible for the malignization of cells.

Immunome, Inc., a biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, today announced the publication of a peer ...

Recent larger-scale studies of patients with cancer and longitudinal population cohorts have revealed how age-related expansions of mutant hematopoietic cells (clonal hematopoiesis [CH]) have ...