Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...
Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the ...
Autophagy is essentially the 'rubbish collection' of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson's can result. In their latest ...
A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy. This ...
Autophagy is a natural, conserved process where cells degrade and recycle their own components, including damaged proteins and organelles. This targeted removal is orchestrated by cargo receptors, ...
Mitochondria are central hubs for cellular stress adaptation, with their function integrated with both apoptosis and autophagy pathways that determine cell fate. Alterations in mitochondrial ...
Combining proteasome inhibitors with autophagy inhibitors disrupts acute myeloid leukemia (AML) cells' proteostasis, ...
A study has identified a biological mechanism that could lead to more effective treatments for breast cancer that has metastasized to the brain. A study led by researchers from the University of ...
Autophagy—meaning “self-eating” in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...
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