A team has identified a previously unknown phase of the immune response. The results challenge long-standing assumptions about the process called 'T-cell priming'. These new insights have significant ...

Many different cancer treatments work to directly target the tumor or the cells around it. The immediate goal is to mitigate ...

Recent innovations include engineering CAR T-cells to overcome the immunosuppressive tumour microenvironment and enhancing their ability to infiltrate solid tumours.

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to ...

Removing EPO signaling in mouse liver tumors leads to tumor regression along with sensitivity to immunotherapy.

Role of CD2-CD58 interactions in clinical antitumor T cell responses. Image Credit: Sino Biological US Inc. The CD2-CD58 axis is pivotal in immune function and is a key target for developing new ...

The GPC3-CAR T cells were found to be safe, with peak cell expansion at two-weeks post-infusion; however, no objective ...

They observed that factors secreted by T cells boosted CTL function ... These results suggest that IL-3-activated basophils play a role in enhancing CTL antitumor responses. “This was not what I ...

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“The use of NKT cells as effectors in allogeneic CAR-T therapy represents a promising strategy, offering not only direct cytotoxicity but also indirect anti-tumour activity through the priming ...