More information: Silvia Vaena et al, Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response, Cell Reports (2021). DOI: 10.1016/j.celrep.2021. ...

The application of CAR-T cell therapy against solid tumors is often hindered by the dense and rigid tumor extracellular ...

A team of researchers from the Changchun Institute of Applied Chemistry has developed a nanogel-based strategy to enhance the ...

A study led by Prof. Liang Xingjie's team from the National Center for Nanoscience and Technology of the Chinese Academy of ...

One therapy being pursued to establish effective antitumor immunity is adoptive T-cell ... et al. CRISPR activation and interference screens decode stimulation responses in primary human T cells.

The less robust antitumor effects of CAR T-cell therapies when evaluated in patients with solid tumor malignancies have been attributed to the complex tumor microenvironment, antigen heterogeneity, ...

Prof. LIANG Xingjie's team from the National Center for Nanoscience and Technology, along with Prof. GONG Ningqiang from the University of Science and Technology of China, has developed a biomimetic ...

Immune checkpoint inhibitors (ICIs) are a type of immunotherapy or cancer treatment that targets specific immune cells known ...

The importance of neoantigens as critical targets for effective antitumor T-cell responses is underlined by (1) the association of tumor mutational burden and efficacy of immune checkpoint inhibition ...

SENTI-202, a chimeric antigen receptor natural (CAR) killer cell therapy, achieved complete remission in patients with acute myeloid leukemia, offering a faster alternative to conventional CAR T ...