Use of donepezil (Aricept), an acetylcholinesterase inhibitor, for 3 weeks failed to demonstrate efficacy in treating fatigue and psychological symptoms of long COVID in a randomized trial from Japan.

Acetylcholinesterase (AChE) is an enzyme that breaks down neurotransmitters including acetylcholine and has an important role in nerve transduction. Despite its important biological role and use as an ...