The next day, the Astros announced that Paredes was going on the ten-day injured list due to a right hamstring strain. They also optioned Cesar Salazar to Triple-A Sugar Land, and recalled Shay Whitcomb and selected Jon Singleton to take their places on the active roster.

Isaac Paredes appeared to injure his right leg while running to first base another in a season full of injuries for Houston.

Injuries has been the theme for the Houston Astros in the 2025 season. Without their superstar slugger Yordan Alvarez for the majority of the year, the resurgent Jeremy Pena later joined Alvarez on the injured list alongside a plethora of pitchers who are either trying to work their way back or are already done for the season.