Mandatory evacuation orders were issued Wednesday due to the Hughes Fire burning near Castaic Lake, north of Santa Clarita.

The blaze, being called the Chambers Fire, was first reported at around 6:10 p.m. near Chambers Street and Gilbert Street, according to the Cal Fire/Riverside County Fire Department. A woman who lost 64 pounds on a compounded form of the weight loss drug semaglutide,

The fire threat remains critical in Southern California, where thousands of residents were under evacuation orders Wednesday as fire crews battled the out-of-control Hughes Fire near Castaic, a suburb in the foothills and mountains of northern Los Angeles County.